Search for Earth-Mass Planets and Dark Matter, Too

Gravitational microlensing is known for baryoninc dark matter searches. Here we show that microlensing also provides a unique tool for the detection of low mass planets (such as earths and neptunes) from the ground. A planetary system forms a binary lens (or, a multi-point lens), and we can determine the mass ratio of the planet with respect to the star and relative distance ($=$ separation/Einstein ring radius) between the star and planet. Such a microlenisng planet search project requires a $\approx 2$ m survey telescope, and a network of $1.5-2$ m follow-up telescopes capable of monitoring stars in the Bulge on a 24-hour basis. During the off-season of the Galactic bulge, this network can be used for dark matter search by monitoring the stars in the LMC and SMC.Comment: 5 pages, submitted to the Proceedings of the Second International Symposium on Sources and Detection of Dark Matter in the Univers

Superluminal Caustics of Close, Rapidly-Rotating Binary Microlenses

The two outer triangular caustics (regions of infinite magnification) of a close binary microlens move much faster than the components of the binary themselves, and can even exceed the speed of light. When $\epsilon > 1$, where $\epsilon c$ is the caustic speed, the usual formalism for calculating the lens magnification breaks down. We develop a new formalism that makes use of the gravitational analog of the Li\'enard-Wiechert potential. We find that as the binary speeds up, the caustics undergo several related changes: First, their position in space drifts. Second, they rotate about their own axes so that they no longer have a cusp facing the binary center of mass. Third, they grow larger and dramatically so for $\epsilon >> 1$. Fourth, they grow weaker roughly in proportion to their increasing size. Superluminal caustic-crossing events are probably not uncommon, but they are difficult to observe.Comment: 12 pages, 7 ps figures, submitted to Ap

Local Hall effect in hybrid ferromagnetic/semiconductor devices

We have investigated the magnetoresistance of ferromagnet-semiconductor devices in an InAs two-dimensional electron gas system in which the magnetic field has a sinusoidal profile. The magnetoresistance of our device is large. The longitudinal resistance has an additional contribution which is odd in applied magnetic field. It becomes even negative at low temperature where the transport is ballistic. Based on the numerical analysis, we confirmed that our data can be explained in terms of the local Hall effect due to the profile of negative and positive field regions. This device may be useful for future spintronic applications.Comment: 4 pages with 4 fugures. Accepted for publication in Applied Physics Letter

A key to room-temperature ferromagnetism in Fe-doped ZnO: Cu

Successful synthesis of room-temperature ferromagnetic semiconductors, Zn$_{1-x}$Fe$_{x}$O, is reported. The essential ingredient in achieving room-temperature ferromagnetism in bulk Zn$_{1-x}$Fe$_{x}$O was found to be additional Cu doping. A transition temperature as high as 550 K was obtained in Zn$_{0.94}$Fe$_{0.05}$Cu$_{0.01}$O; the saturation magnetization at room temperature reached a value of $0.75 \mu_{\rm B}$ per Fe. Large magnetoresistance was also observed below $100$K.Comment: 11 pages, 4 figures; to appear in Appl. Phys. Let

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.

BackgroundRewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions. However, persistent repression has been difficult to achieve in a predictable manner using targeted systems.ResultsHere, we report that persistent epigenetic memory required both a DNA methyltransferase (DNMT3A-dCas9) and a histone methyltransferase (Ezh2-dCas9 or KRAB-dCas9). We demonstrate that the histone methyltransferase requirement can be locus specific. Co-targeting Ezh2-dCas9, but not KRAB-dCas9, with DNMT3A-dCas9 and DNMT3L induced long-term HER2 repression over at least 50 days (approximately 57 cell divisions) and triggered an epigenetic switch to a heterochromatic environment. An increase in H3K27 trimethylation and DNA methylation was stably maintained and accompanied by a sustained loss of H3K27 acetylation. Interestingly, substitution of Ezh2-dCas9 with KRAB-dCas9 enabled long-term repression at some target genes (e.g., SNURF) but not at HER2, at which H3K9me3 and DNA methylation were transiently acquired and subsequently lost. Off-target DNA hypermethylation occurred at many individual CpG sites but rarely at multiple CpGs in a single promoter, consistent with no detectable effect on transcription at the off-target loci tested. Conversely, robust hypermethylation was observed at HER2. We further demonstrated that Ezh2-dCas9 required full-length DNMT3L for maximal activity and that co-targeting DNMT3L was sufficient for persistent repression by Ezh2-dCas9 or KRAB-dCas9.ConclusionsThese data demonstrate that targeting different combinations of histone and DNA methyltransferases is required to achieve maximal repression at different loci. Fine-tuning of targeting tools is a necessity to engineer epigenetic memory at any given locus in any given cell type